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Nature Communications | 我院胡家志实验室揭示线粒体DNA片段可广泛整合入核基因组
2024年11月1日,北京大学生命科学学院、北大-清华生命科学联合中心、北京大学成都前沿交叉生物技术研究院胡家志实验室及合作者在Nature Communications发表了标题为:Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks的研究论文。该项研究中作者采用实验室前期开发的用于系统分析基因编辑产物的高通量测序方法——PEM-seq1,发现在核基因组编辑过程中,线粒体DNA片段可能插入到靶向位点,与此...
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【Chemical Science】我院王初实验室发展了一种高效的EVs蛋白质组学分析流程用于结直肠癌的早筛早诊
近日,北京大学化学与分子工程学院、北大-清华生命科学联合中心、北京大学成都前沿交叉生物技术研究院王初实验室与北医三院林坚课题组、北京大学首钢医院顾晋课题组在Chemical Science杂志上合作发表了题为“A simplified and efficient extracellular vesicle-based proteomics strategy for early diagnosis of colorectal cancer”的研究文章。在这项工作中,作者们建立并优化了一种高效的胞外囊泡(Extracellular vesicles...
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Nature Communications | 我院胡家志实验室揭示线粒体DNA片段可广泛整合入核基因组
2024年11月1日,北京大学生命科学学院、北大-清华生命科学联合中心、北京大学成都前沿交叉生物技术研究院胡家志实验室及合作者在Nature Communications发表了标...
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【Chemical Science】我院王初实验室发展了一种高效的EVs蛋白质组学分析流程用于结直肠癌的早筛早诊
近日,北京大学化学与分子工程学院、北大-清华生命科学联合中心、北京大学成都前沿交叉生物技术研究院王初实验室与北医三院林坚课题组、北京大学首钢医院顾晋课...
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【Angew】来鲁华/张长胜团队在全原子蛋白质序列设计中取得新进展
——背景——针对蛋白质结构骨架的序列设计是全新蛋白质设计中的关键问题之一。近年来,随着深度学习方法和技术的发展,全新蛋白质序列设计取得了重要进展。其...
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Cell Systems | 我院林一瀚实验室探究基因调控系统中“记忆”的规律原理与干预策略
生命科学发展的重要途径之一,是通过生命系统的定量解析,提炼运作规律及设计原理,以实现复杂生命系统的可预测干预、设计、及合成。在生命系统中,基因调控网...
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喜报 | 祝贺我院伊成器教授、刘志博教授荣获第六届“科学探索奖”
祝贺我院伊成器教授、刘志博教授分别在医学科学领域、化学新材料领域荣获第六届“科学探索奖”!“科学探索奖”的初衷是支持青年科技工作者勇攀科学高峰。作为...
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Nature Methods | 我院何爱彬团队开发单细胞药物基因组靶点检测新技术解析表观耐药机制
小分子药物与基因组的结合构成了广泛的疾病治疗的分子基础,包括传统药物和靶向治疗。尽管大量的小分子药物通过与基因组互作的效果在临床治疗中得到了充分验证...
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Anti-aging Research Laboratory
Han, JingdongPeking University Boya Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient of The National Science Fund for Distinguished Young Scholars of ChinaRecipient of “ Hundred Talents Program” from The Chinese Academy of SciencesRecipient of “The National New Century Talents Project” of ChinaResearch Field:The laboratory independently resear...

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Cell-free Epi-diagnostics and Drug Multi-omics Laboratory
He, AibinPeking University Boya Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient of The National Science Fund for Distinguished Young Scholars of ChinaOverseas High-level Talent Introduction Program for Young Scholars of ChinaChief Scientist,National Key R&D Program of ChinaResearch Field:The laboratory is clinically oriented, focusing on the deve...

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Immunogenomics Laboratory
Hu, JiazhiPeking University Boya Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient of The National Science Fund for Distinguished Young Scholars of ChinaRecipient of Qiushi Outstanding Youth AwardOverseas High-level Talent Introduction Program for Young Scholars of ChinaResearch Field:The immune system protects us from infection or diseases by effe...

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Intelligent Biomolecular Design and Development Laboratory
Lai, LuhuaPeking University Boya Distinguished ProfessorChangjiang Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient of The National Science Fund for Distinguished Young Scholars of ChinaDean, Peking University Chengdu Academy for Advanced Interdisciplinary BiotechnologiesProfessor,College of Chemistry and Molecular Engineering, Peking UniversityRe...

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Synthetic Biology Laboratory
Lin, YihanPeking University Boya Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient of The National Science Fund for Distinguished Young Scholars of ChinaRecipient of Qiushi Outstanding Youth AwardOverseas High-level Talent Introduction Program for Young Scholars of ChinaResearch Field:The laboratory is dedicated to the application of synthetic biot...

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Novel Boron-containing Drugs Laboratory
Liu, ZhiboPeking University Boya Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient of The National Science Fund for Distinguished Young Scholars of ChinaResearch Field:The laboratory aims to solve the bottleneck problem of boron-containing drugs for boron neutron capture therapy (BNCT for short) in China and achieve technological advancements. It f...

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Quantitative and Systems Biology Laboratory
Tang, ChaoAcademician of Chinese Academy of SciencesChair Professor, Peking UniversityDirector, Center for Quantitative Biology, Peking UniversityDirector,Peking-Tsinghua Center for Life SciencesDirector, Department of Interdisciplinary Sciences, National Natural Science Foundation of ChinaHonorary Dean, Academy for Advanced Interdisciplinary Studies, Peking UniversityPresident, Peking Universi...

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Clinical Chemoproteomics Laboratory
Wang, ChuPeking University Boya Distinguished ProfessorPrincipal Investigator, Peking-Tsinghua Center for Life SciencesRecipient ofTheNational Science Fund for Distinguished Young Scholars of ChinaOverseas High-level Talent Introduction Program for Young Scholars of ChinaDean, Academy for Advanced Interdisciplinary Studies, Peking UniversityDeputy Dean, Peking University Chengdu Academy for Adv...

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